Symposium

Type 2 Immunity in Early Life


Infos

Dates
9 & 10 May 2022
Lieu
Salle académique
Place du 20-Août 7
4000 Liège
Voir la carte
S'inscrire

Gestation through to weaning from our mothers is considered to be a time when immune systems show a bias to Type 2 immunity. The significance of this for mothers and offspring health during pregnancy, nursing and in later life is being recognised as being a key determinant of both positive and negative, short and long term health trajectories.

In this meeting we will present some of the latest insights into how this early life immune status influences important health scenarios and how these effects may be extended into later life once direct maternal offspring interactions have been discontinued. We will be presenting work on how this early life environment influences the control of infection, onset of non-communicable diseases and the maternal-offspring tolerogenic interface. Work will be presented in the context of both developed and developing world health issues.

Venue

Salle académique, Place du 20-Août 7 à 4000 Liège

Accès 

Confirmed invited Speakers

  • Clare Lloyd, Imperial College, London, United Kingdom
    Every little breath: development of allergic immunity in early life
  • Clarissa Prazeres da Costa, Technische Universität München, Munich, Germany
    Fetomaternal immune crosstalk modifies T cell priming through sustained changes to DC function
  • Maria Yazdanbakhsh, Leiden University Medical Center, Leiden, Netherlands
    The immunological footprints generated by different environmental factors
  • Matthew Taylor, Institute of Immunology and Infection Research, University of Edinburgh , United Kingdom
    How does maternal filariasis affect their offspring's Th2 and Regulatory T cell responses?
  • Cecilie Svanes, Bergen University, Norway
    Immunity across generations: The preconception origins of asthma and allergy
  • Jorge Domínguez-Andrés, Radboud University Nijmegen Medical Center, The Netherlands
    Transmission of trained immunity and heterologous resistance to infections across generations
  • Bart Lambrecht, University of Ghent, Belgium
    Influence of perinatal environment on development of type 2 immune responses to allergens in early life

Monday
May 9th, 2022
+

Programme

8:00 to 9:00  –  Registration (Salle Académique – Place du 20-août, Ground floor)

8:30  –  Welcome note:  William Horsnell and Benjamin Dewals

 

9:00  –  Every little breath: development of allergic immunity in early life, Clare Lloyd (Imperial College London, UK)

 

Abstract session 1 (chair: William Horsnell)

9:45 – Maternal probiotic supplementation prevents murine neonatal T helper 2-type asthma: a role for maternal IgG – Justine Smout

10:05  –  Prenatal exposure to ozone triggers development of lung diseases in offspring –  Alison Gillard

10:25 – Suppression of airway allergic eosinophilia by Hp-TGM, a helminth mimic of TGF-ß –  Caroline Chauché

 

10:45 – Coffee break (Salle des professeurs - Place du 20-août, 1st floor)

 

11:30  –  How does maternal filariasis affect their offspring’s Th2 and Regulatory T cell responses? – Matthew Taylor (University of Edingburgh, UK)

 

Abstract session 2 (chair: Hermelijn Smits)

12:15  –  IL-4 receptor signaling regulates lung macrophages during helminth coinfection resulting in enhanced gammaherpesvirus permissiveness – Georgios Petrellis

12:35  –  Maternal γδ T cells shape offspring pulmonary type-2 immunity in a microbiota-dependent manner – Pedro Papotto

12:55  –  MafB and c-Maf regulate the differentiation and identity of lung interstitial macrophages – Wen Peng

 

13:15  –  Lunch and Poster session (Salle des professeurs - Place du 20-août, 1st floor)

 

15:00  –  Transmission of trained immunity and heterologous resistance to infections across generations - Jorge Dominguez-Andrés (Radboud University Medical Center, Nijmegen, NL)

 

Abstract session 3 (chair: David Vermijlen)

15:45  –  A persistent gammaherpesvirus infection reprograms the alveolar macrophage niche for the long-term by dampening type 2 properties of group 2 innate lymphoid cells – Loos Pauline

16:05  –  How does pneumovirus influence antigen presentation in neonatal mice? – Elisabeth Deleeuw

 

16:25  –  Coffee break (Salle des professeurs - Place du 20-août, 1st floor)

 

Abstract session 4 (chair: Benjamin Dewals)

17:00  –  The specific history of viral infections may pave the way for tumor development Lucia Rodriguez-Rodriguez

17:20  –  Single-cell analysis of human fetal and pediatric γδ T cells reveals distinct functional thymic programmingGuillem Sanchez-Sanchez

17:40  –  Altered in utero immune priming through chronic infection in a helminth-endemic region – Esther Ludwig

 

18:00  –  The immunological footprints generated by different environmental factors – Maria Yazdanbakhsh (Leiden University Medical Center, NL)

 

19:00 – Cocktail reception (Salle des professeurs - Place du 20-août, 1st floor)

Tuesday
May 10th, 2022
+

Programme

8:00 –  Welcome coffee (Salle des professeurs - Place du 20-août, 1st floor)

 

9:00 – Influence of perinatal environment on development of type 2 immune responses to allergens in early life – Bart Lambrecht (VIB, UGent, BE)

 

Abstract session 5 (chair: Arnaud Marchant)

9:45    Ly6Chi monocytes balance regulatory and cytotoxic CD4 T cell responses to control virus-induced immunopathology – Céline Maquet

10:05    Humoral immune responses to different Covid-19 vaccine platforms in pregnancy – Larissa De Branbandere

 

10:25 Coffee break (Salle des professeurs - Place du 20-août, 1st floor)

 

11:05 –  Fetomaternal immune crosstalk modifies T cell priming through sustained changes to DC function  Clarissa Prazeres da Costa (Center for Global Health, TUM, München, DE)

 

Abstract session 6 (chair: Laurent Gillet)

11:50  –  Human Plasma Like Media Alters the Activation Phenotype of Neonatal Naïve CD4+ T Cells – Sean Holm

12:10  –  Protecting late-moderate preterm infants from respiratory tract infections and wheeze in their first year of life by using bacterial lysates– Inger van Duuren

 

12:30 –  Immunity across generations: The preconception origins of asthma and allergy  Cecilie Svanes (Centre of International Health, University of Bergen, NO)

 

13:15 –  Lunch and Poster session (Salle des professeurs - Place du 20-août, 1st floor)

 

15:00 –  Integrating maternal and infant immunization strategies - Arnaud Marchant (Université Libre de Bruxelles, BE)

 

Abstract session 7 (chair: Bénédicte Machiels)

15:45  –  Human liver γδ T cells show TCR focusing and increased cytotoxicity in CMV-associated biliary atresia children – Maria Papadopoulou

16:05  –  A role for the tRNA-modifying enzyme Elp3 in tuft cell differentiation and in the immune response in the intestine – Caroline Wathieu

16:25  –  Cord blood immune response differences between Europeans and malaria exposed Africans using mass cytometry – Yoanne Darele Mouwenda

 

16:45 –  Maternal type 2 immunity inherently protects offspring from helminth infection  –  William Horsnell (University of Cape Town, SA)

 

17:30 –  Meeting closure

 

Organizing committee

Registration fees

  • PhD students and postdocs (proof to be provided): 85€
  • Academic staff: 115€
  • Private: 150€
  • Invited speaker: 0€

Practical informations

Accommodation

Access & maps

Abstract submission and registration

  • Extended Abstract submission: March 31th, 2022
  • Registration deadline: April 15th, 2022

There will be a selection among submitted abstracts for oral presentations. To submit an abstract, you must first register using the registration form. You will then receive a link to the abstract submission form.

Contact

For any question:


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Gold sponsors

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Photo by Christian Bowen on Unsplash

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